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Innocoll announced that it will request a Type A meeting with the FDA to respond to several issues, which the Company believes to be addressable and seek details on additional information, if any, will be required. Innocoll said it will disclose additional details in the future after discussions with the FDA. “We expect to work with the FDA over the coming weeks in an effort to address the open issues and to define a path forward for a successful re-filing of our application at the earliest point in time,” said Tony Zook, CEO of Innocoll. get moreIn May, 2016, the Company had announced that two placebo-controlled Phase 3 pivotal studies evaluating XARACOLL (bupivacaine-collagen bioresorbable implant) each achieved the primary endpoint as a postoperative pain relief treatment immediately following open abdominal hernia repair. XARACOLL showed consistency across both studies in treatment effect for pain reduction and opioid reduction. Second Setback The FDA refusal is a second setback for Innocoll in recent months. On November 03, 2016, Innocoll announced that based on top-line data from its COACT-1 and COACT-2 Phase 3 clinical trials of COGENZIA (gentamicin collagen topical matrix) in patients with moderate to severe diabetic foot infections administered in conjunction with systemic antibiotics and wound therapy, the standard of care (SOC), did not meet their primary endpoint of clinical cure of infection after 28 days versus either placebo plus SOC or SOC alone. Stock Performance On Friday, December 30, 2016, following the announcement, Innocoll Holdings’ shares nosedived 61.02%, finishing the day at $0.69. A total volume of 7.83 million shares exchanged hands by the close of the trading session, which was significantly higher than its 3 months average volume of 90.40 thousand shares.

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Performing light stretching exercises of the muscles, tendons, and ligaments under a doctor’s supervision will help relieve the pain and reduce the risks of experiencing it again. So, put your best foot forward to find more about when is the right time to… The most common injury that is likely to cause pain and swelling in the foot and ankle is an ankle sprain. This can arise due to continuous trauma to the retrocalcaneal bursa, which is a jam like sac, located between the Achilles tendon and the heel bone. It could occur due to a fall from a great height or repeated stress. You should continue using an ice compress for a few days until the pain has completely disappeared. 2. There are various treatment methods for treating a sprained ankle, a few of which are given as follows: ✱ If the sprain is mild in nature, the methods of treatment may include keeping the foot in an elevated position, applying cold compress to the affected area and wrapping the leg with a bandage to reduce the swelling. Moreover, this also relieves itching and peeling caused due to athlete’s foot. Causes of Leg Pain During night-time Veins are blood vessels that return de oxygenated blood to the heart.

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